How does cystic fibrosis affect the kidney ?

This serious genetic disorder causing extensive damage mainly to the respiratory and digestive systems affects the kidneys as well. Generally, it is perceived that cystic fibrosis spares the kidneys, but there is an increase in incidences where patients of cystic fibrosis (CF) are reporting renal diseases.

Nearly 65% women with cystic fibrosis are likely to develop stress incontinence or urine leakage arising from cough, sneezing, lifting weight and laughing. About 6% of adult patients having CF develop kidney stones and 40% of them will face recurrences.

CF patients suffering from chronic diarrhea often show altered oxalate absorption which may gradually lead to the formation of calcium containing kidney stones. Higher levels of uric acid and reduced levels of citrate in the urine of such patients also favor formation of kidney stones.

Cystic fibrosis mainly affects the lungs and digestive system, but kidney-related complications can sometimes occur indirectly.

People with cystic fibrosis may develop kidney problems because of:

• Long-term medication use
• Dehydration
• Repeated infections
• High salt imbalance in the body

Some antibiotics used frequently in cystic fibrosis treatment may affect kidney function over time if not monitored properly. Kidney stones are also reported more commonly in some patients.

Doctors usually monitor hydration, nutrition, and kidney health regularly in long-term cystic fibrosis care.

Modern treatment has improved life expectancy and overall disease management significantly, but regular medical supervision remains extremely important because cystic fibrosis can affect multiple organs over time.