What is Acute Lymphoblastic Leukemia ? - letsdiskuss
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Anonymous

medical student | Posted on | Health-beauty


What is Acute Lymphoblastic Leukemia ?


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Visiting Consultant Physician, Rockland hospital, Dwarka | Posted on


Normally, blood contains 3 cell types like RBC,WBC and platelets which are formed in inner portion of our bones which is called ' ***** marrow'. Sometimes due to some reasons, the stem cells which form WBC in the ***** marrow starts proliferation at a rapid but disorganised pace causing accumulation of immature WBC cell types which is unable to perform functions of normal WBC. Due to accumulation of these immature cells other cell types like RBC and platelets are also produced at decreased rate causing Anemia , thrombocytopenia along with leukopenia (decreased normal WBC). These accumulating immature cells progressively start spilling in the blood circulation from ***** marrow and infiltrate lymph nodes, liver ,spleen and other organs of the body causing various types of symptoms.

Letsdiskuss

(Blood Journal)


Usually, most common age group affected by ALL is 0-14 yrs and after 50 yrs. It is most common cancer type in children.


SYMPTOMS

A) Anemia- weakness, dizziness
B) Leukopenia- recurrent infection
C) Thrombocytopenia- recurrent bleeding
D) ***** pain
E) ***** of lymph nodes
F) Abdominal discomfort due to enlarged spleen or liver.
Sometimes, pt is without any symptoms and ALL is diagnosed on routine blood tests .

TYPES:
a)Pre B cell- most common
b)B cell
c)T cell

CAUSES:
ALL is caused mainly due to genetic and chromosomal changes which may be inherited or acquired.
Inherited conditions which increases risk of ALL are down syndrome, kleinfelter syndrome and others.
Acquired conditions include radiation exposure, chemical exposure or someviral infection like HTLV infection.

DIAGNOSIS
Routine blood test like hemogram, LFT, KFT
Peripheral blood smear
***** marrow examination
Flow cytometry and immunohistochemistry
Genetic study
Imaging- chest X ray, CT scan, USG abdomen.

TREATMENT
Treatment of ALL typically lasts for about 2 years with a combination of medicines. It is often intense, especially in the first few months of treatment, so it's important that you are treated in a center that has experience with this disease.
The treatment approach for children with ALL can be slightly different from that used for adults.
In current practice, most adult patients (except the most elderly and those with significant comorbidities) are offered allogeneic ***** marrow transplantation.



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| Posted on


Acute lymphoblastic leukemia is a type of blood and bone marrow cancer that mainly affects the while blood cells in the body.

This decease progresses rapidly and create immature blood cells rather than the matured ones.

Symptoms -
1. Bone pain
2. Gum bleeding
3. Enlarged lymph nodes
4. Bruising
5. Fever
6. Frequent infection

Treatments -
chemotherapy or targeted drugs that specifically kill cancer cells can help treating Acute lymphoblastic leukemia.


Letsdiskuss


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@student | Posted on


Acute lymphoblastic Leukemia is a type of cancer that affects a person's blood and ***** marrow. Abbreviated as ALL, this problem is mainly characterized by overproduction of immature white blood cells. This is known as Lymphoblasts or leukemia blasts. ALL leads to problems like Anaemia, recurrent infection and frequent bruising and bleeding. The reason for occurrence of these disease is the inefficiency of the ***** marrow to produce red blood cells, white blood cells and platelets. These cells than separate from the ***** marrow and clog different organs like lymph nodes etc.

This cancer can be classified into different types:

@ Pre-B-cell All: This is generally found in adult cases wherein ALL occurs in B-lymphocytes in the early stages of ***** marrow development, thus known as precursor B-cell ALL.

@ B-cell ALL: A rare case which occurs in mature developing lymphocytes, thus also known as Burkitt type ALL.

@ T-Cell ALL: Occurring in about 20-25% cases,this affects the developing lymphocytes of the body. This type can be further sub categorized into early,mid or late cells depending on their maturity.

In Australia more than 300 cases of ALL are found every year. there is no particular age for this cancer to appear, but it is most commonly found in children of age 0-14 years. It is one of the most common type of leukemiain children

The major symptoms of ALL include anaemia, frequent or unexplained bruising and bleeding, repeated infections, slow healing, ***** and joint pains etc. However, in a lot of cases there were no symptoms and people were Diagnosed with it during routine check-ups.



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| Posted on


Acute lymphocytic leukemia (ALL) is a type of cancer of the blood and ***** marrow — the spongy tissue inside bones where blood cells are made. The word "acute" in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones


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